IL-15 enhances cross-reactive antibody recall responses to seasonal H3 influenza viruses in vitro
Identifieur interne : 000300 ( Main/Exploration ); précédent : 000299; suivant : 000301IL-15 enhances cross-reactive antibody recall responses to seasonal H3 influenza viruses in vitro
Auteurs : Junqiong Huang [République populaire de Chine] ; Shannon P. Hilchey [États-Unis] ; Jiong Wang [États-Unis] ; Jessica Gerigan [États-Unis] ; Martin S. Zand [États-Unis]Source :
- F1000Research [ 2046-1402 ] ; 2017.
Abstract
Url:
DOI: 10.12688/f1000research.12999.1
PubMed: 29479423
PubMed Central: 5801566
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">IL-15 enhances cross-reactive antibody recall responses to seasonal H3 influenza viruses
<italic>in vitro</italic></title><author><name sortKey="Huang, Junqiong" sort="Huang, Junqiong" uniqKey="Huang J" first="Junqiong" last="Huang">Junqiong Huang</name><affiliation wicri:level="1"><nlm:aff id="a1">School of Laboratory Medicine, Zunyi Medical University, Zunyi Guizhou, 563099, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Laboratory Medicine, Zunyi Medical University, Zunyi Guizhou, 563099</wicri:regionArea><wicri:noRegion>563099</wicri:noRegion></affiliation></author><author><name sortKey="Hilchey, Shannon P" sort="Hilchey, Shannon P" uniqKey="Hilchey S" first="Shannon P." last="Hilchey">Shannon P. Hilchey</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jiong" sort="Wang, Jiong" uniqKey="Wang J" first="Jiong" last="Wang">Jiong Wang</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author><author><name sortKey="Gerigan, Jessica" sort="Gerigan, Jessica" uniqKey="Gerigan J" first="Jessica" last="Gerigan">Jessica Gerigan</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author><author><name sortKey="Zand, Martin S" sort="Zand, Martin S" uniqKey="Zand M" first="Martin S." last="Zand">Martin S. Zand</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29479423</idno><idno type="pmc">5801566</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801566</idno><idno type="RBID">PMC:5801566</idno><idno type="doi">10.12688/f1000research.12999.1</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000962</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000962</idno><idno type="wicri:Area/Pmc/Curation">000962</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000962</idno><idno type="wicri:Area/Pmc/Checkpoint">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000221</idno><idno type="wicri:Area/Ncbi/Merge">000E56</idno><idno type="wicri:Area/Ncbi/Curation">000E56</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E56</idno><idno type="wicri:Area/Main/Merge">000300</idno><idno type="wicri:Area/Main/Curation">000300</idno><idno type="wicri:Area/Main/Exploration">000300</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">IL-15 enhances cross-reactive antibody recall responses to seasonal H3 influenza viruses
<italic>in vitro</italic></title><author><name sortKey="Huang, Junqiong" sort="Huang, Junqiong" uniqKey="Huang J" first="Junqiong" last="Huang">Junqiong Huang</name><affiliation wicri:level="1"><nlm:aff id="a1">School of Laboratory Medicine, Zunyi Medical University, Zunyi Guizhou, 563099, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Laboratory Medicine, Zunyi Medical University, Zunyi Guizhou, 563099</wicri:regionArea><wicri:noRegion>563099</wicri:noRegion></affiliation></author><author><name sortKey="Hilchey, Shannon P" sort="Hilchey, Shannon P" uniqKey="Hilchey S" first="Shannon P." last="Hilchey">Shannon P. Hilchey</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jiong" sort="Wang, Jiong" uniqKey="Wang J" first="Jiong" last="Wang">Jiong Wang</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author><author><name sortKey="Gerigan, Jessica" sort="Gerigan, Jessica" uniqKey="Gerigan J" first="Jessica" last="Gerigan">Jessica Gerigan</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author><author><name sortKey="Zand, Martin S" sort="Zand, Martin S" uniqKey="Zand M" first="Martin S." last="Zand">Martin S. Zand</name><affiliation wicri:level="1"><nlm:aff id="a2">Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Nephrology, University of Rochester Medical Center, Rochester , NY, 14642</wicri:regionArea><wicri:noRegion>14642</wicri:noRegion></affiliation></author></analytic><series><title level="j">F1000Research</title><idno type="eISSN">2046-1402</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background: </bold>Recently, several human monoclonal antibodies that target conserved epitopes on the stalk region of influenza hemagglutinin (HA) have shown broad reactivity to influenza A subtypes. Also, vaccination with recombinant chimeric HA or stem fragments from H3 influenza viruses induce broad immune protection in mice and humans. However, it is unclear whether stalk-binding antibodies can be induced in human memory B cells by seasonal H3N2 viruses.</p><p><bold>Methods:</bold> In this study, we recruited 13 donors previously exposed to H3 viruses, the majority (12 of 13) of which had been immunized with seasonal influenza vaccines. We evaluated plasma baseline strain-specific and stalk-reactive anti-HA antibodies and B cell recall responses to inactivated H3N2 A/Victoria/361/2011 virus
<italic>in vitro</italic> using a high throughput multiplex (mPlex-Flu) assay.</p><p><bold>Results: </bold>Stalk-reactive IgG was detected in the plasma of 7 of the subjects. Inactivated H3 viral particles rapidly induced clade cross-reactive antibodies in B cell cultures derived from all 13 donors. In addition, H3 stalk-reactive antibodies were detected in culture supernatants from 7 of the 13 donors (53.8%). H3 stalk-reactive antibodies were also induced by H1 and H7 subtypes. Interestingly, broadly cross-reactive antibody recall responses to H3 strains were also enhanced by stimulating B cells
<italic> in vitro </italic>with CpG
<sub>2006 </sub>ODN in the presence of IL-15. H3 stalk-reactive antibodies were detected in CpG
<sub>2006</sub> ODN + IL-15 stimulated B cell cultures derived from 12 of the 13 donors (92.3%), with high levels detected in cultures from 7 of the 13 donors.</p><p><bold>Conclusions:</bold> Our results demonstrate that stalk-reactive antibody recall responses induced by seasonal H3 viruses and CpG
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J" uniqKey="Miller J">J Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krause, Jc" uniqKey="Krause J">JC Krause</name></author><author><name sortKey="Tsibane, T" uniqKey="Tsibane T">T Tsibane</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramirez, A" uniqKey="Ramirez A">A Ramirez</name></author><author><name sortKey="Co, M" uniqKey="Co M">M Co</name></author><author><name sortKey="Mathew, A" uniqKey="Mathew A">A Mathew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melchionda, F" uniqKey="Melchionda F">F Melchionda</name></author><author><name sortKey="Fry, Tj" uniqKey="Fry T">TJ Fry</name></author><author><name sortKey="Milliron, Mj" uniqKey="Milliron M">MJ Milliron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Lee, Ps" uniqKey="Lee P">PS Lee</name></author><author><name sortKey="Hoffman, Rm" uniqKey="Hoffman R">RM Hoffman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Junqiong" sort="Huang, Junqiong" uniqKey="Huang J" first="Junqiong" last="Huang">Junqiong Huang</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Hilchey, Shannon P" sort="Hilchey, Shannon P" uniqKey="Hilchey S" first="Shannon P." last="Hilchey">Shannon P. Hilchey</name></noRegion><name sortKey="Gerigan, Jessica" sort="Gerigan, Jessica" uniqKey="Gerigan J" first="Jessica" last="Gerigan">Jessica Gerigan</name><name sortKey="Wang, Jiong" sort="Wang, Jiong" uniqKey="Wang J" first="Jiong" last="Wang">Jiong Wang</name><name sortKey="Zand, Martin S" sort="Zand, Martin S" uniqKey="Zand M" first="Martin S." last="Zand">Martin S. Zand</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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